齐发国际APP

何创龙传授

何创龙,博士。东华大先生物工程系主任,传授,博士生导师。重庆大先生物医学工程专业博士,同济大学和密歇根大学(公派)博士后。次要从事生物质料、生物制造、纳米医学等范畴的讲授和科研事情。先后获上海市天然迷信奖、桑麻奖教金等奖项。掌管科技部、国度天然迷信基金委、教诲部、上海市科委等赞助的科研项目20余项;在海内外学术期刊上揭晓论文186篇,含ESI高被引论文2篇、SCI封面论文4篇;获受权国度发现专利27项;为国际华人骨研学会 (ICMRS) 终身会员;任中国参与医学家当手艺创新同盟常务理事、中国骨质松散防治同盟首创理事、上海市生物医学工程学会生物质料专业委员会副主任委员、中国医药教诲协会医用生物质料与手艺专业委员会副主任委员、中国机器工程学会生物制造工程分会常务委员、中国剖解学会血管分会常务委员等职务。任140多个国际期刊的审稿人。

  

研讨偏向:

1. 生物质料与构造工程;

2. 生物墨水与生物制造;

3. 用于癌症诊断与医治的生物纳米手艺。

 

声誉及获奖情形:

1. 第三届天下大先生生命迷信比赛一等奖(2019年)

2. 香港桑麻基金会桑麻奖教金(2018年)

3. 第三届天下大先生生命迷信创新创业大赛指点西席一等奖(2018年)

4. 上海市迷信手艺奖天然迷信三等奖(2015年)

  

掌管的次要科研项目:

1.国度重点研发设计课题(2018YFB1105602),细胞与基质质料一体化的构造适配性生物墨水及打印手艺研发,2018.5-2021.4

2.国度天然迷信基金面上项目(31771048)诊疗一体化骨支架的仿生构建与骨再生的静态监测,2018.1-2021.12

3. 国度天然迷信基金面上项目(31570984),促血管祖细胞召募的小口径血管支架构建与原位再生研讨,2016.1-2019.12

4. 国度天然迷信基金面上项目(31271028),双因子法式开释的骨支架构建及促血管化和成骨活性研讨,2013.1-2016.12

5.教诲部地方高校根本科研营业费学科交织重点设计项目(2232018A3-07),基于多模态影像手艺的可视化构造工程研讨,2018.1-2020.12

6. 上海市科委国际互助项目,聚酯弹性体的分解及3D打印血管植入物的使用研讨,2019.11-2022.11

7.上海市科委国际科技互助项目(15540723400),石墨烯基纳米骨支架的构建及其在骨缺损医治中的使用,2015.10-2018.9

8.上海市教委科研创新重点项目(13ZZ051),外场作用下的电化学协同堆积与仿生骨支架研讨,2013.1-2015.12

9. 上海市天然迷信基金(11ZR1400100),纳米纤维的电化学协同自组装修饰及具有血管化潜能的骨支架研讨,2011.4.1-2014.3.31

10. 上海市天然迷信基金(07ZR14001),纤维卵白纳米纤维构造工程血管的根底研讨,2007.12-2009.11

11.上海市科委纳米科技项目(11nm0505500),具有诱导血管天生和成骨活性的纳米纤维骨修复质料研讨,2011.11-2014.9

12. 教诲部留学返国职员科研启动基金,具有促血管化潜能的复合纳米纤维骨支架的研讨,2012.1-2014.12

13.教诲部博士点基金(200802551014),纳米纤维的电化学仿生矿化及用于骨支架质料的研讨,2009.1-2011.12

14. 上海市白玉兰科技人才基金(2010B001),无机/无机复合骨构造工程支架的研讨,2010.6-2011.5

 

代表性学术论文:

1.Yang SG, Chen L, Zhou XJ, Sun P, Fu LW, You YL, Xu M, You ZW, Kai GY*, He CL*. Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics. Chem. Eng. J. 2019; 378: 122171.

2. Liu DH, Nie W, Li DJ, Wang WZ, Zheng LX, Zhang JT, Zhang JL, Peng C, Mo XM, He CL*. 3D printed PCL/SrHA scaffold for enhanced bone regeneration. Chem. Eng. J. 2019; 362: 269-279.

3. Chen L, Zhou XJ, He CL*. Mesoporous silica nanoparticles for tissue engineering applications. WIRES Nanomed. Nanobi. 2019; 11(6): e1573.

4. Chen L, Zhang JL, Zhou XJ, Yang SG, Zhang QQ, Wang WZ, You ZW, Peng C*, He CL*. Merging metal organic framework with hollow organosilica nanoparticles as versatile nanoplatform for cancer theranostics. Acta Biomater. 2019; 86: 406-415.

5. Wang WZ, Nie W, Zhou XJ, Feng W, Chen L, Zhang QQ, You ZW, Shi QS*, Peng C*, He CL*. Fabrication of heterogeneous porous bilayered nanofibrous vascular grafts by two-step phase separation technique. Acta Biomater. 2018; 79: 168-181.

6. Chen L, Zhou XJ, Nie W, Feng W, Zhang QQ, Wang WZ, Zhang YZ, Chen ZG, Huang P*, He CL*. Marriage of albumin-gadolinium complexes and MoS2 nanoflakes as cancer theranostics for dual-modality magnetic resonance/photoacoustic imaging and photothermal therapy. ACS Appl. Mater. Interfaces. 2017; 9 (21):17786-17798.

7. Chen L, Feng YH, Zhou XJ, Zhang QQ, Nie W, Wang WZ, Zhang YZ, He CL*. One-pot synthesis of MoS2 nanoflakes with desirable degradability for photothermal cancer therapy. ACS Appl. Mater. Interfaces. 2017; 9 (20): 17347-17358.

8. Nie W, Peng C, Zhou XJ, Chen L, Wang WZ, Zhang YZ, Ma PX*, He CL*. Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering. Carbon. 2017; 126: 325-337.

9.Chen L, Zhou XJ, Nie W, Zhang QQ, Wang WZ, Zhang YZ, He CL*. Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging. ACS Appl. Mater. Interfaces. 2016, 8 (49): 33829-33841.

10. Qiu KX, Chen B, Nie W, Zhou XJ, Feng W, Wang WZ, Chen L, Mo XM, Wei YZ, He CL*. Electrophoretic deposition of dexamethasone-loaded mesoporous silica nanoparticles onto poly(L-lactic acid)/poly(ε–caprolactone) composite scaffold for bone tissue engineering. ACS Appl. Mater. Interfaces. 2016; 8 (6): 4137-4148.

11. Zhou XJ, Feng W, Qiu KX, Chen L, Wang WZ, Nie W, Mo XM, He CL*. BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells. ACS Appl. Mater. Interfaces. 2015; 7 (29): 15777-15789.

12. Feng W, Zhou XJ, Nie W, Chen L, Qiu KX, Zhang YZ, He CL*. Au/polypyrrole@Fe3O4 nanocomposites for MR/CT dual-modal imaging guided- photothermal therapy: an in vitro study. ACS Appl. Mater. Interfaces. 2015; 7(7): 4354-4367.

13. Feng W, Nie W, Cheng YH, Zhou XJ, Chen L, Qiu KX, Chen ZG*, Zhu MF, He CL*. In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications. Nanomedicine: NBM. 2015; 11(4): 901-912.

14. He CL*, Nie W, Feng W. Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering. J. Mater. Chem. B. 2014; 2(45): 7828-7848.

15. Feng W, Nie W, He CL*, Zhou XJ, Chen L, Qiu KX, Wang WZ, Yin ZQ. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers.  ACS Appl. Mater. Interfaces. 2014; 6 (11): 8447-8460.

16. He CL, Jin XB, Ma PX. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation. Acta Biomater. 2014; 10(1): 419-427.

17. He CL*, Zhang F, Cao LJ, Feng W, Zhang YZ, Wang HS, Mo XM, Wang JW. Rapid mineralization of porous gelatin scaffolds by electrodeposition for bone tissue engineering. J. Mater. Chem. 2012; 22(5): 2111-2119.

18. He CL, Xiao GY, Jin XB, Sun CH, Ma PX. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Adv. Funct. Mater. 2010; 20(20):3568-3576.

 

主授课程:

初级构造工程学(博士生);构造工程(硕士生)

生物质料学(本科生)

 

联络德律风:021-67792666                                                 Emailhcl@dhu.edu.cn