齐发国际APP

史朝阳传授

 

    史朝阳,19708月生,化学化工与生物工程学院,生物迷信与手艺研讨所传授,博士生导师,校特聘传授。2008年返国前,在美国密歇根大学历任博士后研讨员、第二级副研讨员、研讨员和研讨助理传授。美国化学会、中国化学会、中国生物质料委员会会员,上海市生物物理学会理事,北京心理迷信会再生医学专业委员会秘书长、副主任委员。兼任美国密歇根大学医学和生物迷信纳米手艺研讨所客座研讨员,首届葡萄牙马德拉大学约请纳米手艺主任(Invited Chair in Nanotechnology),Wiley-VCH期刊Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol.副主编,美国化学会期刊Bioconjugate Chem.编委;也是Nat. Nanotechnol.Nat. Commun. J. Am. Chem. Soc.84个国际杂志审稿人。

  

研讨偏向:

1.生物纳米手艺:以种种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台,研讨种种癌症的晚期诊断、多模态诊断、医治、团结医治及诊疗一体化。

2.新型纳米质料和纳米复合质料的分解、组装、外面修饰、功能、及其在生物医学中的使用。

3.静电纺纳米纤维在生物医学和情况迷信中的使用。

 

声誉及获奖情形:

1.   2008获上海高校特聘传授(西方学者)称呼;

2.   2009年,入围首批SCOPUS寻觅将来迷信之星流动天下纳米迷信前10名;

3.   2010年,获首届葡萄牙马德拉大学约请纳米手艺主任(Invited Chair in Nanotechnology称呼;

4.   2011年,获教诲部新世纪优异人才支持设计;

5.   2013年,获上海高校特聘传授(西方学者)跟踪支持设计;

6.   2014年,获第五届中国侨界孝敬奖创新人才奖;

7.   2016年,获中国医疗保健国际交换促进会,中原医学科技奖二等奖;

8.   2017年,获上海市科技提高奖一等奖;

9.   2017年,获中国纺织产业团结会讲授功效奖二等奖;

10. 2018年,获上海市领武士才称呼;

11. 2018年,获上海市天然迷信奖一等奖;

12. 2019年,获上海市优异学术带头人设计。

 

掌管与负担次要项目情形:

 

1.   多功效树状大分子包裹金纳米颗粒基因革新T细胞用于加强免疫医治,科技部国度重点研发设计当局间国际科技创新互助/港澳台科技创新互助重点专项项目(立项编号:2017YFE0196200),2019.08.01-2020.12.31,项目掌管人,在研。

2.   行使活性聚阳离子含磷树状大分子和两亲性树冠为载体团结UTMD手艺加强microRNA克制剂的运送及其三阴性乳腺癌医治使用,国度天然迷信基金国际(区域)互助与交换项目(项目同意号:21911530230),2019.01.01-2021.12.31,项目掌管人,在研。

3.   智能型树状大分子纳米器件的设计及其加强肿瘤免疫医治使用,上海市科委优异学术带头人设计(19XD1400100),2019.05.01-2022.04.30,项目掌管人,在研。

4.   功效性纳米硫化铜负载的纳米凝胶的设计及其光声成像扶引的肿瘤光热医治,国度天然基金委中德迷信基金研讨交换中央互助研讨小组项目(GZ1505)2019.01.01-2021.12.31,项目掌管人,在研。

5.   生物医用高分子,上海市教委上海领武士才,2019.01.01-2021.12.31,项目掌管人,在研。

6.   两性离子修饰的树状大分子纳米平台的修建及其乳腺癌诊疗使用,国度天然迷信基金面上项目 (项目同意号:21773026)2018.01.01-2021.12.31,项目掌管人,在研。

7.   无机/无机纳米杂化平台的构建及其肿瘤精准成像与医治,国度天然迷信基金国际(区域)互助与交换项目,构造间互助研讨—A3前瞻设计项目(中日韩),项目同意号:817611480282017.08.01-2022.07.31,项目掌管人,在研。

8.   具有抗污功能的树状大分子纳米器件的设计及其肿瘤精准诊疗使用,上海市科委当局间国际互助项目(17540712000)2017.07.01-2020.06.30,项目掌管人,在研。

9.   负载抗癌药物的多功效树状大分子包裹的纳米金颗粒用于肿瘤的靶向CT诊断与医治,教诲部博士点基金(20130075110004),博导类,2014.01.01-2016.12.31,项目掌管人,已结题。

10. 纳米生物医用质料与手艺,上海高校特聘传授(西方学者)跟踪设计支持, 2014.1-2016.12,项目掌管人,已结题

11. 多功效杂化纳米水凝胶及其双模态分子影像学使用,中德迷信基金研讨交换中央项目(GZ899)2013.10-2016.9,项目掌管人,已结题

12. DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors,葡萄牙基金委(FCT)项目(PTDC/CTM-NAN/1748/2012, 2013.4-2015.4, 项目掌管人,已结题。

13. 无机/无机纳米复合修复质料及其口腔医学使用开辟,国度高手艺研讨生长设计 (2012AA030309)2012.1-2014.12介入,已结题。

14. 行使树状大分子纳米手艺构建多功效纳米杂化颗粒及其肿瘤CT/MRI双模态成像诊断研讨,国度天然迷信基金面上项目 (项目同意号:21273032)2013.1-2016.12,项目掌管人,已结题。

15. 树状大分子纳米质料及其医学使用,教诲部新世纪人才支持设计,2012.1 -2014.12,项目掌管人,已结题。

16. 多功效磁性氧化铁/金核壳纳米探针的构建及其分子影像诊断使用,上海市科委纳米专项(11nm0506400),2011.12 -2014. 9,项目掌管人, 已结题。

17. 多功效树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研讨,国度天然迷信基金面上项目 (项目同意号:20974019)2010.1-2012.12,项目掌管人,已结题。

18. 多功效树状大分子包裹的纳米金颗粒作为肿瘤CT成像造影剂的研讨,上海市科委浦江人才设计(09PJ1400600),2009.7-2011.7,项目掌管人,已结题。

19. 基于树状大分子的多功效肿瘤成像造影剂的研讨, 上海高校特聘传授(西方学者)嘉奖设计,2008.6-2011.6项目掌管人,已结题。

20. 葡萄牙马德拉大学约请纳米手艺主任基金 (由葡萄牙科技部FCTSantander 银行赞助) 项目掌管人,2010-2018已结题

21. 人工纳米生物机械修建与生物医学使用的根底研讨,973设计(2007CB936000),2007.7-2011.8,介入,已结题。

 

揭晓论著情形:

 

史朝阳传授的次要研讨功效包罗在纳米医学与生物手艺、纳米迷信、质料化学、高分子化学和剖析化学等范畴内共揭晓或承受揭晓了372SCI收录期刊论文,17篇书的章节和303篇集会论文、择要或讲述,并获受权发现专利84项。研讨事情揭晓在Chem. Rev., Chem. Soc. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Adv. Sci., Small, Adv. Funct. Mater.Biomaterials等等专业杂志上。此中影响因子跨越3.0以上的文章有288篇,影响因子跨越7.0以上的文章有73篇。文章总援用数跨越15955次,单篇援用最高次数为486次,H-index71

 

2015年以来揭晓的代表论著:

1.     Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen*, Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 10.273, citation #213).

2.     Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth Möhwald, Helena Tomás,* Xiangyang Shi*. RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells. ACS Appl. Mater. Interfaces2015, 7 (8), 4833-4843 (impact factor 8.456, citation #76, ESI paper).

3.     Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen, Xiangyang Shi,* Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces2015, 7(9), 5420-5428 (impact factor 8.456, citation #42).

4.     Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl. Mater. Interfaces2015, 7 (11), 6331–6339 (impact factor 8.456, citation #160).

5.     Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2015, 44, 1–27 (Impact factor 24.505, citation #83).

6.     Yulin Li*, Dina Maciel, João Rodrigues*, Xiangyang Shi*, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chem. Rev.2015,115 (16), 8564–8608 (impact factor 54.301, citation #197).

7.     Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi*, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for SPECT Imaging and Radiotherapy of Gliomas. ACS Appl. Mater. Interfaces2015, 7 (35), 19798–19808 (impact factor 8.456, citation #44).

8.     Hongdong Cai#, Kangan Li#, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small2015, 11 (35), 4584-4593 (impact factor 10.856, citation #79).

9.     Xin Li#, Zuogang Xiong#, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces2016, 8, 19883-19891 (impact factor 8.456, citation #36).

10.  Aijun Li, Benqing Zhou, Carla S. Alves, Bei Xu, Rui Guo, Xiangyang Shi,* Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles. ACS Appl. Mater. Interfaces2016, 8 (39), 25808–25817 (impact factor 8.456, citation #12).

11.  Peng Wang#, Jia Yang#, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Antifouling manganese oxide nanoparticles: Synthesis, characterization, and applications for enhanced MR imaging of tumors. ACS Appl. Mater. Interfaces 2017, 9 (1), 47-53 (impact factor 8.456, citation #19).

12.  Wenjie Sun#, Sabrina Thies#, Jiulong Zhang, Chen Peng*, Guangyu Tang, Mingwu Shen, Andrij Pich*, Xiangyang Shi*. Gadolinium-Loaded Poly(N-vinylcaprolactam) Nanogels: Synthesis, Characterization, and Application for Enhanced Tumor MR Imaging. ACS Appl. Mater. Interfaces 2017, 9 (4), 3411-3418 (impact factor 8.456, citation #28).

13.  Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827 (impact factor 8.456, citation #66).

14.  Lingdan Kong#, Lingxi Xing#, Benqing Zhou, Lianfang Du*, Xiangyang Shi*. Dendrimer-Modified MoS2 Nanoflakes as a Platform for Combinational Gene Silencing and Photothermal Therapy of Tumors. ACS Appl. Mater. Interfaces 2017, 9 (19), 15995–16005 (impact factor 8.456, citation #41).

15.  Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385 (impact factor 8.243, citation #14).

16.  Lizhou Lin#, Yu Fan#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun,Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics2018, 8(7), 1923-1939 (impact factor 8.063, citation #24).

17.  Serge Mignani*, João Rodrigues*, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral*. Dendrimers in combination with natural products and analogues as anti-cancer agents. Chem. Soc. Rev.2018, 47, 514-532 (citation # 41, Impact factor 40.443).

18.  Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146–6154 (impact factor 8.456, citation #11).

19.  Jean-Pierre Majoral*,Maria Zablocka*, Anne-Marie Caminade, Piotr Balczewski,Xiangyang Shi, Serge Mignani*. Interactions gold/phosphorus dendrimers. Versatile ways to hybrid organic-metallic macromolecules.Coord. Chem. Rev.2018, 358, 80-91 (impact factor 13.476, citation #7).

20.  Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev.2018, 47, 1874-1900 (citation # 89, Impact factor 40.443).

21.  Zheng Qiao, Mingwu Shen, Yunchao Xiao, Meifang Zhu, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*. Organic/inorganic nanohybrids formed using electrospun polymer nanofibers as nanoreactors.Coord. Chem. Rev.2018, 372, 31-51 (impact factor 13.476, citation #5).

22.  Jingyi Zhu#, Hongsheng Li#, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi*, Kai Chen*. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Appl. Mater. Interfaces 2018, 10(41), 34954-34964 (impact factor 8.456, citation #14).

23.  Serge Mignani*, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral*. Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis. Adv. Drug Deliver. Rev.2018, 136–137, 73–81 (impact factor 15.519, citation # 12).

24.  Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci.2018, 5, 1801612 (citation #19, Impact factor 15.804).

25.  Jianzhi Zhu#, Zhicong Li#, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi*, Han Wang*, Jan C. M. van Hest*. Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy. Theranostics2019, 9(26), 8048-8060 (impact factor 8.063, citation #0).

26.  Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett.2019, 19, 1216−1226(citation # 6, Impact factor 12.279).

27.  Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J.2019, 362, 842-850 (Impact factor 8.355, citation #9).

28.  Jinyuan Liu, Zhijuan Xiong, Jiulong Zhang, Chen Peng*, Barbara Klajnert-Maculewicz*, Mingwu Shen*, Xiangyang Shi*.Zwitterionic Gadolinium (III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis. ACS Appl. Mater. Interfaces 2019, 11, 15212-15221 (impact factor 8.456, citation #8).

29.  Xin Li#, Shiyi Lu#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci.2019, 6, 1901800 (citation # 3, Impact factor 15.804).

30.  Lingxi Xing#, Xin Li#, Zehua Xing#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J.2020, 382, 122949 (Impact factor 8.355, citation #0).

31.  Ni Zhang, Yue Wang, Changchang Zhang, Yu Fan, Du Li, Xueyan Cao, Jindong Xia, Xiangyang Shi, Rui Guo*. LDH-Stabilized Ultrasmall Iron Oxide Nanoparticles as a Platform for Hyaluronidase-Promoted MR Imaging and Chemotherapy of Tumors. Theranostics2020, 10, 2791-2802 (impact factor 8.063, citation #0).

32.  Changchang Zhang, Wenjie Sun, Yue Wang, Fang Xu, Jiao Qu, Jindong Xia, Mingwu Shen*, Xiangyang Shi*. Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Appl. Mater. Interfaces 2020, 12, 9107-9117 (impact factor 8.456, citation #0).

33.  Fang Xu#, Jianzhi Zhu#, Lizhou Lin#, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du* and Xiangyang Shi*. Redox-responsive PVCL nanogels loaded with MnO2 nanoparticles and doxorubicin for imaging-guided and UTMD-promoted chemotherapy of tumors. Theranostics2020, 10(10), 4349-4358 (impact factor 8.063, citation #0).

34.  Ningning Song, Lingzhou Zhao, Xiaoying Xu, Meilin Zhu, Changcun Liu, Na Sun, Jiqin Yang,* Xiangyang Shi,* Jinhua Zhao*. LyP-1-modified multifunctional dendrimers for targeted anti-tumor and anti-metastasis therapy. ACS Appl. Mater. Interfaces 2020, 12, 12395-12406 (impact factor 8.456, citation #0).

35.  Yu Fan#, Wenzhi Tu#, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu*, Xiangyang Shi*. Targeted Tumor Hypoxia Dual Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers. Adv. Funct. Mater.2020, 30, 1909285 (impact factor 15.621, citation #0).

 

国际交换与互助:

美国密歇根大学、法国国度科研中央共同归天学实行室、法国巴黎大学、德国亚琛产业大学、德国莱布尼茨聚合物研讨所、荷兰埃因霍温理工大学、葡萄牙马德拉大学、匈牙利徳布勒森大学、日本大阪大学、韩国檀国大学、以色列巴伊兰大学、波兰罗茨大学

 

主授课程:

博士研讨生课程:化学前沿、纳米医学和博士生Seminar;本科生课程:纳米医学与生物手艺

 

博士后和研讨生招生信息:

迎接感兴味的具有化学、化工、生物医学、质料、纺织等相干研讨靠山的博士生请求博士后研讨职位,同时迎接感兴味的具有相反靠山的本科生和硕士生报考参加本课题组。

 

联络德律风:021-67792656                                                              EMAILxshi@dhu.edu.cn

( 更新于2020-05-02,上海)