齐发国际APP

陈志龙传授

陈志龙,男,为第二军医大学药学学士、医学博士(药归天学专业),曾先后在中科院上海无机化学研讨所、澳大利亚Central Queensland University、英国The University of Liverpool举行博士后研讨。曾任第二军医大学防护医学教研室主任、学科带头人。现为齐发国际APP化学化工与生物工程学院生物医药研讨组课题组长,PI,药归天学与药理学传授,博士生导师。

为中国光学会激光医学分会常务理事;上海生化药物专业委员会副主任委员;上海药归天学专业委员会委员;国度迷信手艺嘉奖评审专家;科技部严重重点专项评审专家;国度天然迷信基金评审专家;教诲部设计项目与博士点基金评审专家;上海市科委项目评审专家。

揭晓论文300余篇。出书中英文专著4部。请求国度发现专利80余项。

 

研讨偏向:

1)光敏新药研发及光动力疗法的根底与使用研讨(如抗肿瘤、抗鲜红斑痣、抗类风湿性枢纽炎、抗菌抗病毒作用等);

2)分子靶向药物研讨(如降压新药血管重要素受体拮抗剂的设计分解与活性研讨;抗肿瘤新药STING受体冲动剂研讨;叶酸、多肽等靶向分子导向的新药研讨);

3)药物纳米靶向制剂研讨;

4)自然活性产品新药及中药古代化研讨;

5)转化医学研讨。

 

次要研讨功效:

1)在光动力新药研制及光动力疗法根底与使用研讨范畴做出了精彩成就,处于海内抢先,国际上有肯定影响力。有2个光敏新药进入临床研讨,1个举行临床前研讨。

2)创制了1个高效、长效、低毒的沙坦类降压新药,正在举行临床前研讨。

3)作为次要成员介入研发的国度一类抗肿瘤新药CM-Na已获准上市,该项目获国度发现二等奖。

4)发明了一个新的无机化学反映--三联吡啶的重排反映,该反映在制备具有特别光化学与光生物医学功能的三联吡啶化合物及其金属共同物范畴具有主要用处。

5)在药物纳米靶向通报剂型研讨范畴,在新药药理评价模子构建、新药评价方式研讨等范畴也做出了肯定成就。

6)在新药仿制与医药中心体制备工艺研讨范畴做出了精彩成就。茶碱类系列产物、氨基葡萄糖系列产物在企业完成家当化,产值过亿元。

 

声誉及获奖情形:

1、第二军医大学 “学习成才十佳先辈小我私家” (2001)

2、上海市“浦江人才”(2006);

3、南京市“创新创业人才”(2012);

4、上海市优异学术手艺带头人2015年);

5、嘉兴市“科技领武士才”(2019年)

6、掌管项目光敏新药与试剂的研制及光动力疗法的根底与使用研讨获上海市药学科技二等奖(2012年)。

7、掌管项目光敏新药与试剂的研制及光动力疗法的根底与使用研讨获中国药学科技三等奖(2013年)。

8、介入项目(第二卖力人)光动力医治皮肤病要害手艺创新及推行使用中华医学科技三等奖(2017年)。

9掌管,平湖市创新创业大赛一等奖----光敏新药与试剂及降压新药研讨开辟(2018年)。

 

负担的项目:

负担各种项目80余项,此中掌管50余项,介入30余项。如掌管各种人才基金5项、国度天然迷信基金6项、部队医药卫生严重课题1项、上海市科委与教委重点项目6项、国际互助项目5项等。介入国度与国际主要课题6项,如国度新药创制严重专项、国度天然迷信基金重点项目等;指点团队成员获国度天然基金5项、国度与上海市博士后基金10项、上海市科委重点项目6项等。部门课题如下:

1、国度天然迷信基金(编号:213720423097361130271534300708622987205521977016)。

2、上海市优异学术手艺带头大家才设计基金(编号:15XD1523400)。

3、上海市浦江人才设计基金(编号:06PJ14001)。

4、国度科技部国际互助基金(编号:6-11)。

5、上海市科委严重重点基金(编号:174319026001541196040015431904100141409035001343190070006431902010DZ05023001052nm049001543190410014431906200等)。

6、上海市科委国际科技互助基金(编号:1843071300017430741800174307119001343072230011BA1400700等)。

7、部队医药卫生严重项目(编号01L054)。

8、上海市教委重点项目基金(编号:10ZZ45)。

 

揭晓论文:揭晓论文300余篇,此中近5年揭晓SCI论文40余篇。部门论文如下:

1.         Zhuo Wu, Yi-Jia Yan,Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of AT1 receptor blockers derived from 6-substituted aminocarbonyl benzimidazoles. European Journal of Medicinal Chemistry, 2020, in press. published online DOI: org/10.1016/j.ejmech.2019.07.056.

2.         Ying-Hua Gao, Vanda Lovreković, Zhi-Long Chen*, et al. The photodynamic activities of dimethyl 131-[2-(guanidinyl)ethylamino] chlorin e6 photosensitizers in A549 tumor. European Journal of Medicinal Chemistry, 2019, 177, 144-152.

3.         Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al.Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity. European Journal of Medicinal Chemistry, 2018, 160, 146-156.

4.          Xiaolu Bao, Weibo Zhu, Zhilong Chen*, et al. Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists. European Journal of Medicinal Chemistry, 2016, 123,115-127.

5.         Weibo Zhu, Xiaolu Bao, Zhilong Chen*, et al. N-phenyl indole derivatives as AT1 antagonists with anti-hypertension activities: design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2016, 115,161-178.

6.         Hongyu Tan, Ioannis Houpis, Zhilong Chen*, et al. Olefin preparation via palladium-catalyzed oxidative de-azotative and de-sulfitative internal cross-coupling of sulfonylhydrazones. Organic Letters, 2015,17(14)3548-3551.

7.         Dan Wu, Shane Cheung, Zhi-Long Chen and Donal F. O’Shea, et al. Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome. Chemical Communications, 2015, 51(93):  16667-16670.

8.         Zhuo Wu, Xiao-Lu Bao, Zhi-Long Chen*, et al.. Design, synthesis and biological evaluation of 6-benzoxazole benzimidazole derivatives with anti-hypertension activities. ACS Medicinal Chemistry Letters, 2019, 10, 40 - 43.

9.         Ping-Yong Liao, Xin-Rong Wang, Zhi-Long Chen*, et al. Synthesis of 2-morpholinetetraphenylporphyrins and their photodynamic activities. Bioorganic Chemistry, 2017, 71: 299 - 304.

10.     Li Wang, Wei Zhu, Zhi-Long Chen*, et al. Preparation of a chlorophyll derivative and investigation of its photodynamic activities against cholangiocarcinoma. Biomedicine & Pharmacotherapy. 2017, 92: 285-292.

11.     Lei-Lei Bao, Donal F. O’Shea*, Zhi-Long Chen*, et al. In vitro and in vivo evaluation of a pyropheophorbide-a derivative as a potential photosensitizer for age-related macular degeneration. Biomedicine & Pharmacotherapy, 2017, 88: 1220-1226.

12.     Dan Wu, Shane Cheung, Zhi-Long Chen, Donal F. O'Shea, et al. A DIE responsive NIR-fluorescent cell membrane probe. Biochimica et Biophysica Acta - Biomembranes. 2018, 1860, 2272–2280.

13.     Xiang-Hua Zhang, Li-Jun Zhang, Zhi-Long Chen*, et al. Photodynamic efficiency of a chlorophyll-a derivative in vitro and in vivo. Biomedicine & Pharmacotherapy, 2016, 81, 265-272.

14.    Li-Jun Zhang, Donal O’Shea, Zhi-Long Chen*, et al. Evaluation of a bacteriochlorin-based photosensitizer’s anti-tumor effect in vitro and in vivo. Journal of Cancer Research and Clinical Oncology, 2015, 14111: 1921-1930.

15.    Hongyu Tan, Ioannis Houpis*, Zhilong Chen*, et al. Palladium-catalyzed coupling of sulfonylhydrazones with heteroaromatic 2-amino-halides (Barluenga Reaction): exploring the electronics of the sulfonylhydrazone. Organic Process Research & Development. 2015, 19(8), 1044-1048.

16.     Li-Jun Zhang, Yi-Jia Yan, Zhi-Long Chen*, et al. Antitumor activity evaluation of meso-tetra (pyrrolidine substituted) pentylporphin-mediated photodynamic therapy in vitro and in vivo. Journal of Photochemistry & Photobiology, B: Biology. 2016, 163:224-231.

17.     Ping-Yong Liao, Ying-Hua Gao, Zhi-Long Chen*, et al. Tetraphenylporphyrin derivatives possessing piperidine group as potential agents for photodynamic therapy. Journal of Photochemistry & Photobiology, B: Biology. 2016, 165: 213-219.

18.     Xiao-Lu Bao,  Wei-Bo Zhu, Zhi-Long Chen*, et al. Design, synthesis and evaluation of novel angiotensin II receptor 1 antagonists with antihypertensive activities. RSC Advances, 2017, 7: 26401-26410.

19.     Pingyong Liao, Yijia Yan, and Zhilong Chen*, et al. Synthesis, characterization and biological evaluation of a novel biscarboxymethyl-modified tetraphenylchlorin compound for photodynamic therapy. RSC Advances, 2016, 6: 26186 - 26191.

20.     Mengshi Yang, Di Jiang, Zhilong Chen and Jun Chen, Photodynamic therapy of drug-resistant human colon adenocarcinoma using verteporfin loaded TPGS nanoparticle with tumor homing and penetrating peptide functionalized. RSC Advances, 2016, 6: 100984-100992.

21.     Dan Wu, Shane Cheung, Zhi-long Chen, and Donal F. O'Shea. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances, 2016, 6: 87373-87379.

22.     Sonja Srdanovic, Ying-Hua Gao, Davor Margetic*, Zhi-Long Chen*. The photodynamic activity of 131-[2’-(2-pyridyl)ethylamine] chlorin e6 photosensitizer in human esophageal cancer. Bioorganic & Medicinal Chemistry Letters. 2018, 28(10): 1785-1791.

23.     Wei Zhu, Yi-Jia Yan, Zhi-Long Chen*, et al. Synthesis and biological evaluation of 173-dicarboxylethyl pyropheophorbide-a amide derivatives for photodynamic therapy. Bioorganic & Medicinal Chemistry Letters. 2018, 28: 2784-2788.

24.     Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al. Synthesis and evaluation of new 5-aminolevulinic acid derivatives as prodrugs of protoporphyrin for photodynamic therapy. Photochemical & Photobiological Sciences. 2017, 16: 1623-1630.

25.     Ping-Yong Liao, Xinrong Wang, Zhi-Long Chen*, et al. Synthesis, photophysical properties and biological evaluation of b-alkylaminoporphyrin for photodynamic therapy. Bioorganic & Medicinal Chemistry, 2016, 24(22) : 6040-6047. 

26.     Xiaolu Bao, Weibo Zhu, Zhilong Chen*, et al. Synthesis and evaluation of novel angiotensin II receptor 1 antagonists as anti-hypertension drugs. Bioorganic & Medicinal Chemistry, 2016, 24(9):2023-2031.

27.    Weibo Zhu, Yajing Da,Dan Wu, Zhilong Chen*, et al. Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities. Bioorganic & Medicinal Chemistry. 2014, 22(7): 2294-2302. 

28.     Hongyu Tan, Ioannis Houpis*, Zhilong Chen*, et al. Olefin synthesis by the Pd-catalyzed cross coupling on sulfonylhydrazones with aromatic sulfinates.  Tetrahedron Letters, 2016, 57(21): 2336-2340.

29.    Li-Jun Zhang, Jun Bian, Zhi-Long Chen*, et al. Photosensitizing effectiveness of a novel chlorin-based photosensitizer for photodynamic therapy in vitro and in vivo. Journal of Cancer Research and Clinical Oncology, 2014, 140(9): 1527-1536.

30.    Anamarija B., Zeljko M., Zhi-Long Chen, Davor M. Synthesis of chlorins by Diels–Alder cycloadditions of pheophorbide a and its derivatives, Synlett. 2015, 26 (07): 991-994.

 

国际交换与互助:

与英国利物浦大学、爱尔兰都柏林大学、爱尔兰皇家内科学院、美国新泽西立大学、澳大利亚中昆士兰大学、克罗地亚鲁德尔博斯科维奇研讨所、俄罗斯国度迷信中央、南非罗德斯大学等多所大学与研讨一切互助干系。

 

解说课程:

新药研讨开辟学、新药研发导论、根底无机化学实行

 

研讨团队:

团队成员30余名,含博士助手2名、化学与生物医学博士后2名、博士硕士研讨生二十余名、留先生6名。

 

博士后雇用:

招收药学、化学、生物学、根底医学、防备医学、质料学等专业博士后。

 

博士、硕士研讨生招生:

在化学、生归天学与分子生物学、生物与医药、生物医学工程、质料学等专业的博士、硕士点,招收药学、化学、生物学、医学、质料学等专业靠山研讨生。

 

失业远景:

本课题组研讨偏向失业远景好。

 

德律风:021-67792654                                                                  E-mailzhlchen@dhu.edu.cn